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DENYS V. VOLGIN, Ph.D.
Research Assistant Professor of Physiology, Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania

Research Areas: Sleep abnormalities, Gene expression profiling
PubMed Link
Contact Information:
Department of Animal Biology, University of Pennsylvania
 Email dvolgin@vet.upenn.edu

PRIMARY AREAS OF RESEARCH:
- Molecular neuropharmacology of sleep and sleep-related respiratory disorders (obstructive sleep apnea).
- Neurobehavioral effects of early developmental alcohol exposure.
- Central control of breathing and its postnatal development.
- Molecular and cellular mechanisms of hypoxia.
- Molecular mechanisms of metabolic disorders (diabetes).

METHODOLOGICAL EXPERTISE:
- In vivo rodent studies with administration of experimental compounds and molecular, physiologic, and behavioral endpoints.
- Quantitative analysis of mRNA and protein markers in tissue microsamples (quantitative RT-PCR and Western blot).
- Molecular profiling at the single-cell level (single-cell RT-PCR, immunocytochemistry, immunohistochemistry).
- Rodent behavioral tests, polysomnographic monitoring and scoring of sleep-wake behavior.

Volgin DV, Lu JW, Stettner GM, Mann GL, Ross RJ, Morrison AR, Kubin L. Time- and behavioral state-dependent changes in posterior hypothalamic GABAA receptors contribute to the regulation of sleep PLoS ONE 9: e86545, 2014.

Stettner GM, Kubin L, Volgin DV Loss of motoneurons in the ventral compartment of the rat hypoglossal nucleus following early postnatal exposure to alcohol Journal of Chemical Neuroanatomy 52: 87-94, 2013.

Volgin DV, Stettner GM, Kubin L Circadian dependence of receptors that mediate wake-related excitatory drive to hypoglossal motoneurons Respiratory Physiology & Neurobiology 188: 301-307, 2013.

Volgin DV, Kubin L Reduced sleep and impaired sleep initiation in adult male rats exposed to alcohol during early postnatal period Behavioural Brain Research : , 2012.

Stettner GM, Kubin L, Volgin DV Antagonism of orexin 1 receptors eliminates motor hyperactivity and improves homing response acquisition in juvenile rats exposed to alcohol during early postnatal period. Behavioural Brain Research 221: 324-8, 2011.

Volgin DV, Malinowska M, Kubin L Dorsomedial pontine neurons with descending projections to the medullary reticular formation express orexin-1 and adrenergic alpha2A receptor mRNA. Neuroscience Letters 459: 115-8, 2009.

Volgin DV, Rukhadze I Kubin L Hypoglossal premotor neurons of the intermediate medullary reticular region express cholinergic markers. Journal of Applied Physiology 105: 1576-84, 2008.

Kubin L, Volgin DV Developmental profiles of neurotransmitter receptors in respiratory motor nuclei. Respiratory Physiology & Neurobiology 164: 64-71, 2008.

Volgin DV Perinatal alcohol exposure leads to prolonged upregulation of hypothalamic GABAA receptors and increases behavioral sensitivity to gaboxadol. Neuroscience Letters 439: 182-6, 2008.

Volgin DV, Kubin L Regionally selective effects of GABA on hypothalamic GABAA receptor mRNA in vitro. Biochemical and Biophysical Research Communications 353: 726-32, 2007.

Ph.D. (Physiology) Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, 1999