New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA


Diplomate, American College of Veterinary Ophthalmologists

Clinical Associate, Ophthalmology, University of Pennsylvania School of Veterinary Medicine

Clinical Specialties: Inherited diseases of the eye in animals
Research Areas: Molecular basis of inherited retinal degeneration in dogs

Contact Information:

Takahashi K, Kwok JC, Sato Y, Aguirre GD, Miyadera K. Extended functional rescue following AAV gene therapy in a canine model of LRIT3-congenital stationary night blindness. Vision Research 209: 108260, 2023.

Ripolles-Garcia A, Murgiano L, Ziolkowska N, Marinho FP, Roszak K, Iffrig S, Aguirre GD, Miyadera K. Natural disease history of a canine model of oligogenic RPGRIP1-cone-rod dystrophy establishes variable effects of previously and newly mapped modifier loci. Human Molecular Genetics : ddad046, 2023.

Gray AP, Sato Y, Miyadera K, Aguirre GD. Novel insights into chorioretinal and juxtapapillary colobomas by optical coherence tomography. Veterinary Ophthalmology 25: 136-143, 2022.

Miyadera K, Santana E, Roszak K, Iffrig S, Visel M, Iwabe S, Boyd RF, Bartoe JT, Sato Y, Gray A, Ripolles-Garcia A, Dufour VL, Byrne LC, Flannery JG, Beltran WA, Aguirre GD. Targeting ON-bipolar cells by AAV gene therapy stably reverses LRIT3-congenital stationary night blindness. Proc Natl Acad Sci U S A 119: e2117038119, 2022.

Sato Y, Gray A, Takahashi K, Dufour V, Lutty G, Miyadera K, Aguirre G. Monocular retinopathy of prematurity-like retinal vasculopathy in a dog. Veterinary Ophthalmology 25: 78-84, 2022.

Miyadera K, Conatser L, Llanga TA, Carlin K, O'Donnell P, Bagel J, Song L, Kurtzberg J, Samulski RJ, Gilger B, Hirsch ML. Intrastromal gene therapy prevents and reverses advanced corneal clouding in a canine model of mucopolysaccharidosis I. Molecular Therapy 28: 1455-1463, 2020.

Das RG, Becker D, Jagannathan V, Goldstein O, Santana E, Carlin K, Sudharsan R, Leeb T, Nishizawa Y, Kondo M, Aguirre GD, Miyadera K. Genome-wide association study and whole-genome sequencing identify a deletion in LRIT3 associated with canine congenital stationary night blindness. Scientific Reports 9: 14166, 2019.

Das Rueben G, Marinho Felipe Pompeo, Iwabe Simone, Santana Evelyn, McDaid Kendra Sierra, Aguirre Gustavo D, Miyadera Keiko Variabilities in retinal function and structure in a canine model of cone-rod dystrophy associated with RPGRIP1 support multigenic etiology. Scientific Reports 7: 12823, 2017.

Forman OP, Hitti RJ, Boursnell M, Miyadera K, Sargan D, Mellersh C Canine genome assembly correction facilitates identification of a MAP9 deletion as a potential age of onset modifier for RPGRIP1-associated canine retinal degeneration. Mammalian Genome 27: 237-45, 2016.

Tanaka N, Dutrow EV, Miyadera K, Delemotte L, MacDermaid CM, Reinstein SL, Crumley WR, Dixon CJ, Casal ML, Klein ML, Aguirre GD, Tanaka JC, Guziewicz KE. Canine CNGA3 gene mutations provide novel insights into human achromatopsia-associated channelopathies and treatment. PLoS One 10: e0138943, 2015.

DVM (Veterinary Medicine) University of Tokyo, Japan, 2005

PhD (Molecular Biology) University of Cambridge, United Kingdom, 2011

Diplomate, American College of Veterinary Ophthalmologists

University of Pennsylvania (2012 to 2015)
Residency in Ophthalmology