MICHAEL J. HOGAN
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New Bolton Center Kennett Square, PA
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610-444-5800
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Ryan Hospital Philadelphia, PA
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215-746-8911
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215-746-8387
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MICHAEL J. HOGAN, BS, PhD

Assistant Professor, University of Pennsylvania School of Veterinary Medicine Department of Pathobiology

Cell and Molecular Biology Graduate Group (GTV, MVP), University of Pennsylvania
Research Areas: Non-classical MHC restriction, Cryptic/unconventional T cell epitopes, Protective immunity to viral infections, mRNA vaccine development
PubMed Link
Contact Information:
3800 Spruce Street
216A Rosenthal Bldg

My research interests relate to understanding how protective immune responses are generated against viral diseases, with focuses on: the impact and mechanisms of unconventional T cell responses (e.g. non-classical MHC restriction, non-canonical open reading frames, and other unconventional epitopes), elucidating the interactions between CD4 T cells, CD8 T cells, and B cell responses to protect from viral illnesses, mechanisms of mRNA vaccine immunogenicity, and testing the immunogenicity of various mRNA vaccine designs in different animal species.

Hogan, M. J., Maheshwari, N., Begg, B. E., Nicastri, A., Hedgepeth, E. J., Muramatsu, H., Pardi, N., Miller, M. A., Reilly, S. P., Brossay, L., Lynch, K. W., Ternette, N., Eisenlohr, L. C. Cryptic MHC-E epitope from influenza elicits a potent cytolytic T cell response Nature Immunology 24: 1933-1946, 2023.

Hogan, M. J., Pardi, N. mRNA vaccines in the COVID-19 pandemic and beyond Annual Review of Medicine 73: 17-39, 2022.

Verbeke, R., Hogan, M. J., Lore, K., Pardi, N. Innate immune mechanisms of mRNA vaccines Immunity 55: 1993-2005, 2022.

Saunders, K. O., Pardi, N., Parks, R., Santra, S., Mu, Z., Sutherland, L., Scearce, R., Barr, M., Eaton, A., Hernandez, G., Goodman, D., Hogan, M. J., Tombacz, I., Gordon, D. N., Rountree, R. W., Wang, Y., Lewis, M. G., Pierson, T. C., Barbosa, C., Tam, Y., Matyas, G. R., Rao, M., Beck, Z., Shen, X., Ferrari, G., Tomaras, G. D., Montefiori, D. C., Weissman, D., Haynes, B. F. Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates npj Vaccines 6: 50, 2021.

Pardi, N., Hogan, M. J., Weissman, D. Recent advances in mRNA vaccine technology Current Opinion in Immunology 65: 14-20, 2020.

Laczko, D., Hogan, M. J., Toulmin, S. A., Hicks, P., Lederer, K., Gaudette, B. T., Castano, D., Amanat, F., Muramatsu, H., Oguin, T. H., 3rd, Ojha, A., Zhang, L., Mu, Z., Parks, R., Manzoni, T. B., Roper, B., Strohmeier, S., Tombacz, I., Arwood, L., Nachbagauer, R., Kariko, K., Greenhouse, J., Pessaint, L., Porto, M., Putman-Taylor, T., Strasbaugh, A., Campbell, T. A., Lin, P. J. C., Tam, Y. K., Sempowski, G. D., Farzan, M., Choe, H., Saunders, K. O., Haynes, B. F., Andersen, H., Eisenlohr, L. C., Weissman, D., Krammer, F., Bates, P., Allman, D., Locci, M., Pardi, N. A single immunization with nucleoside-modified mRNA vaccines elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice Immunity 53: 724-732 e7, 2020.

Lederer, K., Castano, D., Gomez Atria, D., Oguin, T. H., 3rd, Wang, S., Manzoni, T. B., Muramatsu, H., Hogan, M. J., Amanat, F., Cherubin, P., Lundgreen, K. A., Tam, Y. K., Fan, S. H. Y., Eisenlohr, L. C., Maillard, I., Weissman, D., Bates, P., Krammer, F., Sempowski, G. D., Pardi, N., Locci, M. SARS-CoV-2 mRNA vaccines foster potent antigen-specific germinal center responses associated with neutralizing antibody generation Immunity 53: 1281-1295 e5, 2020.

Bresk, C. A., Hofer, T., Wilmschen, S., Krismer, M., Beierfuss, A., Effantin, G., Weissenhorn, W., Hogan, M. J., Jordan, A. P. O., Gelman, R. S., Montefiori, D. C., Liao, H. X., Schmitz, J. E., Haynes, B. F., von Laer, D., Kimpel, J. Induction of tier 1 HIV neutralizing antibodies by envelope trimers incorporated into a replication competent vesicular stomatitis virus vector Viruses 11: , 2019.

Hogan, M. J., Conde-Motter, A., Jordan, A. P. O., Yang, L., Cleveland, B., Guo, W., Romano, J., Ni, H., Pardi, N., LaBranche, C. C., Montefiori, D. C., Hu, S. L., Hoxie, J. A., Weissman, D. Increased surface expression of HIV-1 envelope is associated with improved antibody response in vaccinia prime/protein boost immunization Virology 514: 106-117, 2018.

Pardi, N., Hogan, M. J., Porter, F. W., Weissman, D. mRNA vaccines - a new era in vaccinology Nature Reviews: Drug Discovery 17: 261-279, 2018.

Pardi, N., Hogan, M. J., Naradikian, M. S., Parkhouse, K., Cain, D. W., Jones, L., Moody, M. A., Verkerke, H. P., Myles, A., Willis, E., LaBranche, C. C., Montefiori, D. C., Lobby, J. L., Saunders, K. O., Liao, H. X., Korber, B. T., Sutherland, L. L., Scearce, R. M., Hraber, P. T., Tombacz, I., Muramatsu, H., Ni, H., Balikov, D. A., Li, C., Mui, B. L., Tam, Y. K., Krammer, F., Kariko, K., Polacino, P., Eisenlohr, L. C., Madden, T. D., Hope, M. J., Lewis, M. G., Lee, K. K., Hu, S. L., Hensley, S. E., Cancro, M. P., Haynes, B. F., Weissman, D. Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses Journal of Experimental Medicine 215: 1571-1588, 2018.

Pardi, N., Hogan, M. J., Pelc, R. S., Muramatsu, H., Andersen, H., DeMaso, C. R., Dowd, K. A., Sutherland, L. L., Scearce, R. M., Parks, R., Wagner, W., Granados, A., Greenhouse, J., Walker, M., Willis, E., Yu, J. S., McGee, C. E., Sempowski, G. D., Mui, B. L., Tam, Y. K., Huang, Y. J., Vanlandingham, D., Holmes, V. M., Balachandran, H., Sahu, S., Lifton, M., Higgs, S., Hensley, S. E., Madden, T. D., Hope, M. J., Kariko, K., Santra, S., Graham, B. S., Lewis, M. G., Pierson, T. C., Haynes, B. F., Weissman, D. Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination Nature 543: 248-251, 2017.

Boyd, D. F., Peterson, D., Haggarty, B. S., Jordan, A. P., Hogan, M. J., Goo, L., Hoxie, J. A., Overbaugh, J. Mutations in HIV-1 envelope that enhance entry with the macaque CD4 receptor alter antibody recognition by disrupting quaternary interactions within the trimer Journal of Virology 89: 894-907, 2015.

BS (Biochemistry) Brown University, 2011

PhD (Cell and Molecular Biology) University of Pennsylvania, 2017

Children's Hospital of Philadelphia (2017 to 2023)
Postdoctoral Fellow, Immunology