Iron-Refractory Iron Deficiency Anemia (IRIDA)

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Related Terms: Iron-handling Disorder

Type: DNA

Sample Types: Cheek brushes/swabs or Fresh EDTA blood

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Birth

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Sample Processing

Cost: $75.00

Species and Breeds
Canine - American Cocker Spaniel
Canine - English Cocker Spaniel

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Signs become apparent at a young age and include lethargy, weight loss, growth retardation, exercise intolerance, and weakness.

Autosomal recessive

Unpublished

Explanation of Results
Genotype Phenotype Interpretation
2-2 (Homozygous Disease Variant) Unhealthy (Affected) Homozygous Affecteds (2-2) are expected to develop signs consistent with Iron-Refractory Iron Deficiency Anemia (IRIDA) and all of their offspring will inherit a disease variant allele. Parents, offspring and relatives should also be tested. You may choose to contact us for a consultation on the management of this disease. 1 = Normal allele; 2 = Variant allele.
1-2 (Heterozygous) Healthy (Carrier) Heterozygous Carriers (1-2) are not expected to develop signs of Iron-Refractory Iron Deficiency Anemia (IRIDA) but each of their offspring has a chance of inheriting a disease variant allele. Parents, offspring and relatives should also be tested. 1 = Normal allele; 2 = Variant allele.
1-1 (Homozygous Normal) Healthy (Normal, Clear) Homozygous Normals (1-1) are not expected to develop signs of Iron-Refractory Iron Deficiency Anemia (IRIDA) and none of their offspring will inherit the disease variant allele. 1 = Normal allele; 2 = Variant allele.

Naigamwalla DZ, Webb JA, Giger U. Iron deficiency anemia. Can Vet J. 2012 Mar;53(3):250-6. PMID: 22942439; PMCID: PMC3280776.