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blindness-story

Commonalities in Late Stages of Different Inherited Blinding Diseases Suggest Targets for Therapy

Gene therapy holds promise for treating a variety of diseases, including some inherited blinding conditions. But for a gene therapy to be effective, one must know the precise gene responsible for a given individual’s disorder and develop a tailored treatment. For diseases that may be caused by mutations in many different genes, developing individual gene therapy approaches can be prohibitively costly and time-intensive to pursue.
chmi-story

Penn Vet launches new platform to accelerate microbiome research

Studies of the microbiome—the array of bacteria, fungi, viruses, and other microorganisms living in or on a given individual or environment—generate a lot of data. An investigation of the skin microbiome of people with eczema, for example, would include not only the identities of the microbes present, but also a vast amount of metadata, or data about the data, such as the sex, age, weight, and disease status of the individuals under study. Analysis tools that integrate metadata have the potential to reveal connections between the microbiome and clinical outcomes.
hunter-story

T Cells Support Long-lived Antibody-producing Cells, Penn-led Team Finds

If you’ve ever wondered how a vaccine given decades ago can still protect against infection, you have your plasma cells to thank. Plasma cells are long-lived B cells that reside in the bone marrow and churn out antibodies against previously encountered vaccines or pathogens.
toxo-story

Parasite Crossing the Blood Brain Barrier

Some 30 percent of the world’s population is chronically infected with Toxoplasma gondii, which can be life-threatening for people with suppressed immune systems.