Chronic kidney disease (CKD) is a major cause of illness in cats, especially as they age. The rate of progression in cats varies from months to years and can often be managed through medical interventions, as well as lifestyle changes including diet. While the disease can be controlled, it is important to understand the underlying causes in an effort to delay onset and develop novel treatments. In this study, we are collecting blood, urine, saliva, and fecal samples in order to identify biomarkers that are unique to these patients. Biomarkers are measurable substances in a living patient that indicate the presence of a specific disease. The goal of the study is to improve outcomes for cats with chronic kidney disease.

Study Duration:

If your cat is enrolled as a healthy control, you will be asked to bring your cat in for one study visit.

If your cat has CKD, you will be asked to bring your cat to a total of 5 study visits over a period of 12 months. A physical examination, blood pressure, blood work, urinalysis, UPC, ultrasound, and radiographs will be performed at these visits.

Eligibility:

• Cats cannot have a history of heart disease requiring diuretics, beta blockers, antithrombotics, or antiarrhythmics (cats with murmurs and asymptomatic heart disease are allowed).
• Cats cannot have a history of uncontrolled hyperthyroidism, diabetes mellitus, cancer, or other clinically significant extra-renal diseases.
• Cats cannot receive therapy with corticosteroids
• Cats must be 7 years of age or older to participate
• Owners must be willing to bring their cat into 5 scheduled visits over 1 year
• Cat must be amendable to handling in hospital

Benefits:

The study will pay for the cost of the study specific procedures including physical exams,  blood and urine processing, as well as any imaging, as outlined in the consent form. All diagnostic results are available to the owner and primary veterinarian for continued monitoring of disease progression and overall health.

Contact:

For inquiries regarding this trial, please call 215-573-0302 or email vcic@vet.upenn.edu to further discuss trial specifics. Victoria Anders is the primary clinical research nurse for this trial.