The Small Animal Imaging Facility (SAIF) at the School of Veterinary Medicine was established in 2014 to provide the Penn and Philadelphia research community with a suite of pre-clinical small animal imaging devices. These state-of-the-art instruments offer non-invasive imaging opportunities to study drug, tissue and cellular mechanisms in live animals. This includes optical imaging (bioluminescence, fluorescence, and near-infrared) as well as Ultrasound and Doppler imaging for, but not limited to, research in oncology, cardiology, gynecology, hematology, neuroscience, stem cell and developmental biology.