Clinical signs become apparent after surgery or trauma, which can happen at almost any age. These clinical signs include excessive bleeding and a failure to heal after a given traumatic event or surgery. Dogs with this disease live full lives with the infusion of FFP after a bleeding event and special care is taken to be ready with blood for transfusion during a surgery in the event of a hemorrhage.
Factor VII, also called proconvertin, is an essential element in the coagulation cascade, which is the process by which the body stops bleeding through the formation of clots. Without the ability to form clots, an affected dog may bleed out following tissue trauma, resulting in a premature death.
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