Lethargy, loss of appetite, nasal and ocular discharge, diarrhea, enlarged lymph nodes, hepatomegaly (abnormally enlarged liver), splenomegaly (abnormally enlarged liver).
Slight potential for full life with life-long treatment
Autosomal recessive
Multisystem infections with Mycobacterium avium. Granulomatous inflammation in lymph nodes, tonsils, liver, and spleen and areas of caseous necrosis. The bacteria can be readily identified by Ziehl–Neelsen staining and typed by PCR.
Unpublished
Explanation of Results
| Genotype |
Phenotype |
Interpretation |
| 2-2 (Homozygous Disease Variant) |
Unhealthy (Affected) |
Homozygous Affecteds (2-2) are expected to develop signs consistent with Avian Tuberculosis (MAC) and all of their offspring will inherit a disease variant allele. Parents, offspring and relatives should also be tested. You may choose to contact us for a consultation on the management of this disease. 1 = Normal allele; 2 = Variant allele. |
| 1-2 (Heterozygous) |
Healthy (Carrier) |
Heterozygous Carriers (1-2) are not expected to develop signs of Avian Tuberculosis (MAC) but each of their offspring has a chance of inheriting a disease variant allele. Parents, offspring and relatives should also be tested. 1 = Normal allele; 2 = Variant allele. |
| 1-1 (Homozygous Normal) |
Healthy (Normal, Clear) |
Homozygous Normals (1-1) are not expected to develop signs of Avian Tuberculosis (MAC) and none of their offspring will inherit the disease variant allele. 1 = Normal allele; 2 = Variant allele. |
Eggers JS, Parker GA, Braaf HA, Mense MG. Disseminated Mycobacterium avium infection in three miniature schnauzer litter mates. J Vet Diagn Invest. 1997 Oct;9(4):424-7. doi: 10.1177/104063879700900416. PMID: 9376436.
Miller MA, Greene CE, Brix AE. Disseminated Mycobacterium avium--intracellulare complex infection in a miniature schnauzer. J Am Anim Hosp Assoc. 1995 May-Jun;31(3):213-6. doi: 10.5326/15473317-31-3-213. PMID: 7634054.
