Until a month ago, it’s possible to never have heard of coronavirus, despite the fact that science has known about this family of seven viruses since the 1960s. Four are common, causing mild or moderate respiratory symptoms like a runny nose and sore throat, all of which dissipate quickly.
Toxoplasma gondii is best known as the parasite that may lurk in a cat’s litter box. Nearly a third of the world’s population is believed to live with a chronic Toxoplasma infection. It’s of greatest concern, however, to people with suppressed immune systems and to pregnant women, who can pass the infection to their fetuses.
More sure-footed and confident by the day, the U litter puppies of the Working Dog Center are not yet 3 months old, yet are already a month into their training to use their agile bodies and sensitive noses to serve society.
These changes require energy. In a study using a new, genetically altered mouse model, researchers led by Rumela Chakrabarti of Penn’s School of Veterinary Medicine have uncovered a key protein involved in supplying the mammary gland with fuel during puberty. It’s a protein that her group had earlier shown to play a role in triple-negative breast cancer (TNBC), a particularly aggressive form of the disease
A treatment called extracorporeal shockwave therapy (ESWT) is used in patients both human and equine to speed healing of injured tendons and ligaments. Using high-pressure sonic waves, ESWT is thought to increase blood flow to the treated area, and has been shown to reduce pain over the short term.
[December 9, 2019; PHILADELPHIA, PA – Three researchers from the School of Veterinary Medicine at the University of Pennsylvania (Penn Vet) are among the recipients of the annual Innovation awards from the Penn Center for Innovation (PCI), which recognizes the six most significant scientific discoveries or partnerships at the University of Pennsylvania during the preceding twelve months.
For patients with cutaneous leishmaniasis, a skin infection transmitted by a sand fly that can lead to painful and disfiguring ulcers, treatment can be grueling. The first-line therapy offered to many requires daily infusions of the metalloid pentavalent antimony for three weeks, and half of patients don’t respond to just one round of therapy. Some fail two or even three courses. And the side effects of therapy can range from mere irritation to far more serious conditions.
Dogs that are spayed at a young age have a reduced risk of developing mammary tumors, the canine equivalent of breast cancer. Early spaying reduces levels of estrogen production, leading many veterinarians and scientists to cast estrogen in a negative light when it comes to mammary cancer.
Penn Vet and the Pennsylvania Game Commission (PGC) recently initiated the Pennsylvania Wildlife Futures Program (WFP), a new science-based, wildlife health program that will increase disease surveillance, management and innovative research aimed at better protecting wildlife across the Commonwealth.
Given the dazzling array of dog breeds, from dachshunds to mastiffs, from poodles to bloodhounds, it’s easy to forget that most of that diversity arose only in the last few centuries or so, thanks to human tinkering. People have bred dogs for their looks, but the lion’s share of breeding efforts have taken aim at eliciting particular behaviors, according to the University of Pennsylvania’s James A. Serpell.
Creating an effective gene therapy for inherited diseases requires three key steps. First, scientists must identify and characterize the disease. Second, they must find the gene responsible. And finally, they must find a way to correct the impairment.
[PHILADELPHIA, September 12, 2019] - A new core facility, the first on the east coast to exclusively focus on the isolation and characterization of extracellular vesicles, has opened at the University of Pennsylvania’s School of Veterinary Medicine (Penn Vet). The Extracellular Vesicle Core Facility at Penn Vet supports investigators with the necessary scientific and technical capabilities to define, standardize and monitor research in pathological and physiological conditions.
Nearly two decades ago, a gene therapy restored vision to Lancelot, a Briard dog who was born with a blinding disease. This ushered in a period of hope and progress for the field of gene therapy aimed at curing blindness, which culminated in the 2017 approval of a gene therapy that improved vision in people with Leber congenital amaurosis (LCA), a rare, inherited form of blindness closely related to the condition seen in Lancelot. It represents the first FDA-approved gene therapy for an inherited genetic disease.
Much remains mysterious about the factors influencing human inflammatory bowel disease (IBD), but one aspect that has emerged as a key contributor is the gut microbiome, the collection of microorganisms dwelling in the intestines.
Some cases of the flu are so severe they cause lasting injury to the lungs. New research from the University of Pennsylvania now points to a strategy that may one day offer protection against this damage.
The Leukemia Research Foundation is proud to announce a grant of $100,000 in blood cancer research funding to M. Andres Blanco, Ph.D. from the University of Pennsylvania’s School of Veterinary Medicine in Philadelphia, PA, for the research project titled Dual Targeting of LSD1 and KAT6A to Induce Therapeutic Differentiation in AML. The one-year grant is awarded through the Foundation’s Hollis Brownstein Research Grants Program for New Investigators.
A group of microorganisms known as kinetoplastids includes the parasites that cause devastating diseases such as African sleeping sickness, Chagas disease, and leishmaniasis. They share an ability to adhere to the insides of their insect hosts, using a specialized protein structure. But what if scientists could prevent the parasite from adhering? Would the parasites pass right through the vectors, unable to be passed on to a human?
A veterinary student conducting research into stem cell repair, another studying the use of CAR T cells against canine B cell lymphoma, and a student with an interest in equine neuromuscular disorders and protein aggregate diseases are being recognized for their efforts -- and the promise they hold -- by Boehringer Ingelheim’s Animal Health business.
Many dinosaur species are known from scant remains, with some estimates suggesting 75% are known from five or fewer individuals. Auroraceratops rugosus was typical in this regard when it was named in 2005 based upon a single skull from the Gobi Desert in northwestern China. But that is no longer the case.
While stem cells are often considered essential for regenerative medicine, many of our fully developed somatic tissues already possess great capacity for regeneration.