Penn Vet | Clinical Trial Detail - Clinical Trial for dogs who had a Cranial Cruciate Ligament (CCL) Rupture & TPLO Surgery
New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA

Clinical Trial for dogs who had a Cranial Cruciate Ligament (CCL) Rupture & TPLO Surgery

Feb 1, 2017

Dr. Kimberly Angello is conducting a clinical trial evaluating an oral medication for dogs with knee osteoarthritis following a cranial cruciate ligament (CCL) rupture and meniscal tear that have had a surgical repair with a tibial plateau leveling osteotomy (TPLO). 

The purpose of this study is to evaluate the safety and efficacy of a novel therapeutic on the development and progression of osteoarthritis in dogs. If your dog qualifies for participation in the study, he/she will receive the study medication daily for approximately 1 year; your dog will be randomly assigned to the study medication or a placebo. As part of the study, there are 1 screening visit plus 6 visits post-enrollment over a course of one year.


  • 2 years of age or older
  • Weighing at least 30.0 lbs
  • Diagnosed with unilateral CCL rupture within the last 9 months and TPLO surgery performed no more than 4 months prior to enrollment
  • Currently not on any pain medications
  • Owner must be willing to comply with the visit schedule


  • Orthopedic exam, blood work (CBC/Chemistry), x-rays and CTs
  • All study visits and study medication at no charge
  • Compensation for time and travel 

To Enroll:

Please contact the VCIC at 215 573-0302 or by email at if you would like more information about this study.