Penn Vet | Clinical Trial Detail
New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA

Social determinants of dog behavior

A clinical trial to learn more about how home and neighborhood environments can affect dog behavior.

shelter environmental behavior active

Feasibility and perioperative outcomes regarding ultra-low dose indocyanine green for indirect cholangiography during laparoscopic cholecystectomy in dogs

Laparoscopic cholecystectomy is a minimally invasive surgery to remove the gallbladder. This is commonly performed in people with gallbladder disease such as inflammation, infection, or mucocele formation.

indocyanine canine active

Equine Lameness Study Osteoarthritis

In this double-masked, sham-controlled, randomized study, VH-750 will be administered intra-articularly to horses with mild to moderate limb lameness caused by joint OA (fetlock, carpal, or coffin joints).

active osteoarthritis equine

Clinical and Safety Evaluation of Anti-inflammatory Delivery from Mechanically-Activated Microspheres in Canines Presenting with Spontaneous Cranial Cruciate Ligament Disease

A novel anti-inflammatory delivery system for dogs with rupture of the cranial cruciate ligament in one knee joint, which is stabilized with the TPLO surgical procedure

knee injury CCL injury CCL disease CCL tear ACL orthopedic orthopedic surgery knee surgery knee tibial plateau leveling osteotomy cruciate surgery cranial cruciate ligament cruciate injury stifle cruciate disease cruciate tear CCL TPLO active Kimberly Agnello

Pilot study of Frunevetmab (Solensia) and Meloxicam for palliative therapy of feline bone-invasive oral squamous cell carcinomas

This study will be the first to assess whether Solensia, in combination with meloxicam, provides superior pain relief compared to meloxicam alone.

cancer active Solensia carcinoma cancer anti-inflammatory active

Embolization or chemoembolization in dogs with hepatocellular carcinoma and utility of contrast-enhanced ultrasound versus CT angiogram in post-embolization assessment.

This trial will compare outcomes in dogs treated with embolization vs. chemoembolization and will also evaluate the accuracy of contrast enhanced ultrasound verses CT angiogram for post-embolization assessment.

cancer active liver tumors liver cancer hepatocellular carcinoma Embolization dogs with liver tumors dogs with liver cancer CT angiogram Contrast-enhanced ultrasound Chemoembolization active

Evaluation of VetResQ® Hemoperfusion Cartridge for Treatment of Non-Steroidal Anti-Inflammatory Drug (NSAID) Toxicity in Dogs and Cats

The aim of this study is to document how much NSAID is removed from the blood during treatment with VetResQ® hemoperfusion cartridge.

Reineke toxicity poisoning NSAID Extracorporeal Therapies active

Intraoperative assessment of marginal tissue after BCS resection using in-vivo topical application of a cathepsin-targeted molecular probe.

Evaluating the efficacy of a new near-infrared imaging agent when applied topically to tumor during surgery in dogs with mammary gland tumors

cancer active NIRI near-infrared imaging mgt mastectomy massie mammary tumor mammary gland tumor mammary carcinoma mammary adenocarcinoma holt clinical trial Holt breast cancer active

Amantadine in conjunction with carprofen for improvement of lameness and pain secondary to osteoarthritis in dogs

The purpose of this study is to determine the efficacy of amantadine in combination with carprofen, a non-steroidal anti-inflammatory drug (NSAID) already approved for use in dogs, to manage refractory pain associated with osteoarthritis in dogs

active osteoarthritis Amantadine Agnello

Intraoperative detection of oral squamous cell carcinoma margins in dogs using cathepsin-activated near-infrared (NIR) imaging

A clinical trial evaluating a new near-infrared (NIR) imaging agent to detect cancerous tissue in dogs with oral squamous cell carcinoma (SCC) during surgical excision.

cancer active surgery squamous cell carcinoma skin cancer SCC oral tumor NIRI near-infrared imaging mouth Holt Griffin epithelium epidermis Castejon cancer active

Use of a newly available glargine (Semglee®) for treatment of diabetes mellitus in cats

This clinical trial will help determine if Semglee is as effective as glargine in regulating diabetes in cats.

Semglee insulin FreeStyle Libre glucose diabetic cat Nelson Mampe Rebecka hess feline diabetes clinical trial active

Untargeted plasma metabolomics and biomarker, DNA, and microbiome assessments in cats with and without chronic kidney disease

This study is looking to identify unique biomarkers in cats with chronic kidney disease and improve outcomes.

urinary clinical trial chronic kidney disease active

Evaluation of FLASH Proton RT in Naturally Occurring Canine Head and Neck Cancer

The purpose of this study is to evaluate the safety and feasibility of a novel form of radiation therapy (RT) called FLASH proton radiation therapy for head and neck cancers in dogs.

cancer active radiation Oncology clinical trial cancer active

Cathepsin-activated near-infrared (NIR) imaging for intraoperative detection of insulinomas

A clinical trial evaluating a new near-infrared imaging agent to detect cancerous tissue in dogs with Insulinoma during surgical excision.

cancer active pancreatic Insulinoma clinical trial cancer active

Evaluation of Bendamustine as a Novel Chemotherapy Agent for Relapsed Canine Lymphoma

The purpose of this study is to evaluate different doses of bendamustine in dogs with lymphoma to evaluate its safety and effectiveness.

cancer active lymphoma dogs chemotherapy active

Fosmidomycin Otic Trial for dogs

Dermatology is currently enrolling in a clinical trial evaluating a novel, topical antimicrobial for dogs with bilateral otitis.

ear infection in dogs canine otitis active

Intraoperative Detection and Resection of Tumors in Canines Using an Integrated Spectroscopy and Imaging System

A clinical trial to determine if near-infrared imaging can improve the surgeon’s ability to see cancer and cancer margins during surgery to remove primary lung tumors in dogs.

cancer active tumor surgery primary lung tumor Oncology metastasis mass margins lung tumor lung mass lung infrared Imaging Dr. David Holt diagnostic imaging comprehensive cancer care canine tumor canine lung tumor canine cancer cancer center cancer advanced imaging active

Coagulation in Septic Peritonitis in Dogs

We are testing a heparin derivative that is anti-inflammatory without being anticoagulant.

abdomen septic belly septic abdomen septic peritonitis active

Long term study assessing outcome of knee arthritis in dogs with cruciate ligament (CCL) rupture

A clinical trial evaluating the outcome of dogs with patellofemoral osteoarthritis due to the rupture of the Cranial Cruciate Ligament in one stifle, then stabilized with the Tibial Plateau Leveling Osteotomy (TPLO) procedure

Dr. Kimberly Agnello VCIC TPLO tibial plateau leveling osteotomy stifle osteoarthritis orthopedic limping ligament rupture knee joint cruciate tear cruciate cranial cruciate ligament CCL arthritis Agnello active ACL